Formyl peptide receptor-2 is decreased in foetal growth restriction and contributes to placental dysfunction

M Lappas; S McCracken; K McKelvey; R Lim; J James; CT Roberts; T Fournier; N Alfaidy; KL Powell; AJ Borg; JM Morris; B Leaw; H Singh; PR Ebeling; EM Wallace; LJ Parry; E Dimitriadis; P Murthi

Journal article

Formyl peptide receptor-2 is decreased in foetal growth restriction and contributes to placental dysfunction

M Lappas, S McCracken, K McKelvey, R Lim, J James, CT Roberts, T Fournier, N Alfaidy, KL Powell, AJ Borg, JM Morris, B Leaw, H Singh, PR Ebeling, EM Wallace, LJ Parry, E Dimitriadis, P Murthi

Molecular Human Reproduction | OXFORD UNIV PRESS | Published : 2018

DOI: 10.1093/molehr/gax067

Abstract

STUDY QUESTION: What is the association between placental formyl peptide receptor 2 (FPR2) and trophoblast and endothelial functions in pregnancies affected by foetal growth restriction (FGR)? SUMMARY ANSWER: Reduced FPR2 placental expression in idiopathic FGR results in significantly altered trophoblast differentiation and endothelial function in vitro. WHAT IS KNOWN ALREADY: FGR is associated with placental insufficiency, where defective trophoblast and endothelial functions contribute to reduced feto-placental growth. STUDY DESIGN, SIZE, DURATION: The expression of FPR2 in placental tissues from human pregnancies complicated with FGR was compared to that in gestation-matched uncomplicated..

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University of Melbourne Researchers

Martha Lappas Author

Evdokia Dimitriadis, Eva Dimitriadis Author

Related Projects (1)

UNDERSTANDING WHAT TRIGGERS BIRTH

Being born too early is the major cause of perinatal morbidity and mortality and accounts for the majority of neonatal deaths. The aim of th..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

P.M. and P.R.E. received funding from the Australian Institute of Musculoskeletal Science, Western Health, St. Albans, Victoria 3021, Australia. M.L. is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; Grant no. 1047025). Monash Health is supported by the Victorian Government's Operational Infrastructure Support Programme. The authors declare that there is no conflict of interest in publishing this work.